{
  "schema_version": "1.0",
  "last_updated": "2026-07-08",
  "drug": "tirzepatide",
  "boxed_warning": "Risk of thyroid C-cell tumors (based on rodent studies). Counsel patients on symptoms of thyroid tumors.",
  "contraindications": [
    "Personal or family history of medullary thyroid carcinoma (MTC)",
    "Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)",
    "Known serious hypersensitivity to tirzepatide or excipients"
  ],
  "warnings_precautions": [
    "Pancreatitis",
    "Hypoglycemia (esp. with insulin/secretagogues)",
    "Acute kidney injury from dehydration",
    "Gallbladder disease",
    "Diabetic retinopathy (in type 2 diabetes)",
    "Severe gastrointestinal disease"
  ],
  "note": "Not for use in pregnancy without clinician guidance. Compounded tirzepatide is not FDA-approved."
}